Deborah P Merke Selected Research

Congenital adrenal hyperplasia due to 21 hydroxylase deficiency

10/2021	Tildacerfont in Adults With Classic Congenital Adrenal Hyperplasia: Results from Two Phase 2 Studies.
2/2021	11-Oxygenated Androgens Useful in the Setting of Discrepant Conventional Biomarkers in 21-Hydroxylase Deficiency.
1/2021	24-Hour Profiles of 11-Oxygenated C19 Steroids and Δ5-Steroid Sulfates during Oral and Continuous Subcutaneous Glucocorticoids in 21-Hydroxylase Deficiency.
7/2020	Androgen excess and diagnostic steroid biomarkers for nonclassic 21-hydroxylase deficiency without cosyntropin stimulation.
12/2018	Complement component 4 variations may influence psychopathology risk in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
11/2017	Congenital adrenal hyperplasia.
11/2017	Revisiting the prevalence of nonclassic congenital adrenal hyperplasia in US Ashkenazi Jews and Caucasians.
1/2017	11-Oxygenated Androgens Are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency.
5/2016	Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency.
3/2015	Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

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Deborah P Merke Research Topics

Disease

60	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 12/2022 - 02/2002
20	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 10/2021 - 02/2002
12	Hyperandrogenism 11/2021 - 02/2002
8	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2019 - 02/2002
7	Cushing Syndrome 12/2015 - 07/2002
5	Insulin Resistance 01/2022 - 05/2002
5	Precocious Puberty 05/2011 - 08/2008
4	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 01/2021 - 02/2013
4	Hyperplasia 01/2019 - 02/2002
3	Virilism (Virilization) 11/2020 - 02/2002
3	Autoimmune Diseases (Autoimmune Disease) 12/2018 - 12/2012
3	Hypoglycemia (Reactive Hypoglycemia) 01/2018 - 02/2004
3	Infertility (Sterility) 01/2016 - 02/2002
2	Obesity 11/2021 - 07/2017
2	Hypertension (High Blood Pressure) 11/2021 - 01/2019
2	Joint Dislocations 01/2018 - 02/2013
2	Joint Instability (Joint Laxity) 01/2018 - 02/2013
2	Arthralgia (Joint Pain) 01/2018 - 02/2013
2	Hirsutism 11/2017 - 01/2017
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 01/2016
2	Weight Gain 01/2016 - 04/2009
2	Female Infertility 01/2016 - 06/2011
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2014 - 07/2009
2	Mental Disorders (Mental Disorder) 11/2010 - 02/2002
2	Mood Disorders (Mood Disorder) 11/2010 - 02/2009
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2005 - 05/2002
1	Lipodystrophy 01/2022
1	Hyperglycemia 11/2021
1	Proteinuria 12/2020
1	Male Infertility (Male Sterility) 12/2019
1	Hernia (Hernias) 01/2018
1	Menstruation Disturbances 11/2017
1	Fatty Liver 07/2017
1	Morbid Obesity 07/2017
1	Weight Loss (Weight Reduction) 07/2017
1	Adrenal Rest Tumor 01/2017
1	Fatigue 12/2016
1	Thyroid Diseases (Thyroid Disease) 02/2016
1	Amenorrhea 01/2016
1	Metabolic Bone Diseases (Osteopenia) 12/2012
1	Schizophrenia (Dementia Praecox) 11/2010

Drug/Important Bio-Agent (IBA)

26	AndrogensIBA 01/2022 - 05/2002
25	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2022 - 02/2002
25	GlucocorticoidsIBA 11/2021 - 05/2002
11	SteroidsIBA 01/2022 - 01/2005
9	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 01/2019 - 05/2004
7	tenascin XIBA 10/2019 - 02/2013
7	AldosteroneIBA 01/2019 - 05/2002
6	Androstenedione (4 Androstene 3,17 dione)IBA 01/2022 - 12/2016
6	Biomarkers (Surrogate Marker)IBA 02/2021 - 02/2002
6	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2020 - 02/2002
6	SaltsIBA 01/2018 - 02/2002
5	Hormones (Hormone)IBA 01/2022 - 12/2004
4	4-(fluoromethyl)phenyl phosphate (FMPP)IBA 05/2011 - 08/2008
4	Epinephrine (Adrenaline)FDA LinkGeneric 02/2010 - 02/2004
3	Testosterone (Sustanon)FDA Link 01/2022 - 02/2009
3	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 02/2021 - 11/2017
3	Cosyntropin (Cortrosyn)FDA LinkGeneric 07/2020 - 11/2012
3	EnzymesIBA 11/2017 - 02/2014
3	Extracellular Matrix ProteinsIBA 01/2016 - 02/2013
2	Insulin (Novolin)FDA Link 01/2022 - 05/2002
2	MineralocorticoidsIBA 11/2021 - 07/2002
2	Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)IBA 01/2019 - 01/2019
2	Complement C4 (Complement Component 4)IBA 12/2018 - 12/2012
2	Progesterone FDA LinkGeneric 10/2018 - 12/2016
2	Gonadal Steroid Hormones (Sex Hormones)IBA 11/2017 - 02/2009
2	Flutamide (Eulexin)FDA LinkGeneric 01/2016 - 07/2002
2	Pharmaceutical PreparationsIBA 12/2013 - 07/2002
2	Glucose (Dextrose)FDA LinkGeneric 08/2007 - 02/2004
2	MetanephrineIBA 07/2002 - 05/2002
1	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 01/2022
1	Insulin ReceptorIBA 01/2022
1	HDL LipoproteinsIBA 11/2021
1	LDL Lipoproteins (beta Lipoproteins)IBA 11/2021
1	Sulfates (Sulfates, Inorganic)IBA 01/2021
1	RNA Splice SitesIBA 01/2021
1	posaconazole FDA Link 12/2020
1	nevanimibeIBA 01/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 03/2019
1	Triglycerides (Triacylglycerol)IBA 01/2019
1	HLA-B Antigens (HLA-B)IBA 11/2017
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 08/2017
1	Pituitary HormonesIBA 01/2017
1	OsteocalcinIBA 12/2016
1	collagen type I trimeric cross-linked peptideIBA 12/2016
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2016
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2016
1	FludrocortisoneIBA 01/2016
1	Combined Oral ContraceptivesIBA 01/2016
1	Glycoproteins (Glycoprotein)IBA 08/2015
1	MineralsIBA 03/2015
1	Fibrillar CollagensIBA 02/2014
1	CollagenIBA 02/2014
1	Vitamin D FDA LinkGeneric 12/2012
1	Cytochrome P450 Family 21IBA 02/2012
1	Peptides (Polypeptides)IBA 02/2012

Therapy/Procedure

11	Therapeutics 01/2021 - 07/2002
3	Adrenalectomy 01/2016 - 01/2005
1	Gastrectomy 07/2017
1	Bariatric Surgery 07/2017